: These cells produce cytokines (IL-4, IL-13) that trigger B cells to differentiate into plasma cells producing allergen-specific IgE.
: Systemic immune priming eventually leads to upper and lower airway inflammation. 3. Key Management Strategies : These cells produce cytokines (IL-4, IL-13) that
: Sensitization through inflamed skin can lead to early-onset food allergies. : These cells produce cytokines (IL-4
Atopy is a genetic predisposition toward developing exaggerated IgE-mediated immune responses to common environmental allergens. Clinically, it manifests as a triad of conditions—, allergic rhinitis (hay fever) , and allergic asthma —often appearing sequentially in a pattern known as the "atopic march". 1. Pathophysiology and Mechanism allergic rhinitis (hay fever)
The core of atopy is a Type I hypersensitivity reaction driven by a Type 2 immune response.
Atopy typically follows a predictable chronological progression:
