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The primary reason for its strict regulation is , meaning it can cause severe, life-altering birth defects if taken during pregnancy.

: In the U.S., patients must enroll in the iPLEDGE program , which requires monthly office visits, regular blood tests (to monitor liver function and cholesterol), and strict pregnancy prevention protocols. can buy accutane over counter

: Beyond birth defects, Accutane can cause significant changes in liver enzymes, dry skin and eyes, mood changes (including depression), and muscle/joint pain. The primary reason for its strict regulation is