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Editorial: The Role of Aire, microRNAs and Cell ... - PMC - NIH

A helpful paper would explain how the AIRE gene functions as a transcriptional regulator in the thymus. It helps "train" the immune system by expressing proteins normally found only in peripheral tissues (like the insulin from the pancreas) within the thymus. This allows the immune system to identify and eliminate self-reactive T-cells before they can cause harm. 2. Autoimmunity and Genetic Variants daniella aire

Modern helpful papers are increasingly moving toward solutions. Recent work includes: Editorial: The Role of Aire, microRNAs and Cell

: Developing treatments like antisense oligonucleotides (ASOs) to reverse abnormal splicing caused by AIRE mutations. Editorial: The Role of Aire