The series explores the early partnership between Will Graham (Hugh Dancy), a man with a "unique way of thinking" that allows him to empathize deeply with psychopaths, and Dr. Hannibal Lecter (Mads Mikkelsen), who is secretly a cannibalistic serial killer known as the .

: Explores Lecter’s life in Italy and the eventual adaptation of the Red Dragon storyline. Key Cast and Characters

: A gifted but vulnerable profiler whose empathy often fractures his own sanity.

: Graham struggles to prove his innocence after being framed by Lecter, leading to a "scrappier" pursuit of the doctor.