The pathology and genetics of urinary system tumours have been significantly updated in the . This latest "Blue Book" shifts the focus toward a more molecular-driven classification while maintaining morphology as the diagnostic groundwork. Key Updates in the 5th Edition
5%) of a high-grade component in a papillary tumour warrants a high-grade diagnosis. Pathology and Genetics of Tumours of the Urinar...
WHO/ISUP grading is now recommended for all RCCs. For bladder tumours, any presence (even ≥is greater than or equal to The pathology and genetics of urinary system tumours
Muscle-invasive bladder carcinoma is now categorized into six molecular subgroups: luminal-papillary, luminal non-specified, luminal-unstable, stroma-rich, basal-squamous, and neuroendocrine-like. WHO/ISUP grading is now recommended for all RCCs
The term "subtype" has officially replaced "variant" for distinct morphologic categories. "Variant" is now reserved specifically for genomic alterations.
Several renal tumours are now defined by their genetic alterations, such as SMARCB1-deficient medullary renal cell carcinoma (RCC), TFEB-altered RCC, and ELOC-mutated RCC.