[s5e22] What A Difference A Day Makes May 2026

: Jeffrey Dean Morgan makes a final appearance as Denny Duquette, appearing as a hallucination to Izzie that Derek and Bailey eventually realize is a symptom of her worsening condition. Behind the Scenes Facts

: To promote the 100th episode, ABC created a real wedding website for Meredith and Derek that fans could actually visit and RSVP to. [S5E22] What a Difference a Day Makes

: After Derek and Bailey discover that Izzie has an inoperable brain tumor, the group decides to celebrate her life and love immediately. : Jeffrey Dean Morgan makes a final appearance

: George O'Malley faces an emotional crisis when almost all the students from the accident die under his care, leaving him devastated until Owen Hunt helps him see the lives he did save. : George O'Malley faces an emotional crisis when

The episode's central plot twist occurs when Meredith and Derek decide to give their meticulously planned wedding to Izzie and Alex.

: As a wedding gift, Derek gives Meredith her first solo surgery—a successful colon surgery overseen by Richard Webber.