SGK1 acts as a "hub" molecule regulating diverse cellular processes:
: To become fully functional, SGK1 undergoes a two-step phosphorylation process: SGK1 4 zip
: The human SGK1 protein is a serine/threonine-protein kinase consisting of 431 amino acids with a molecular mass of approximately 49 kDa . It features an N-terminal PX-like (phox homology) domain, a central catalytic kinase domain, and a C-terminal hydrophobic motif. SGK1 acts as a "hub" molecule regulating diverse
then phosphorylates Threonine 256 within the kinase domain. a central catalytic kinase domain
: Research compounds like EMD638683 , GSK650394 , and SI113 are being studied for their potential to treat cancer, metabolic disorders, and fibrotic diseases. Serum and glucocorticoid-regulated kinase 1 - Frontiers