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It tethers vesicles to the plasma membrane, facilitating sound encoding.

Otoferlin engages the target membrane specifically through a large interface involving the N-terminal C2B and C-terminal C2F-C2G domains . Ca 2+raised to the 2 plus power tm,cc,jp

Sensing: The C2D domain is identified as critical, as disruptions in this area alter synaptic sound encoding. It tethers vesicles to the plasma membrane, facilitating

ions are bound per domain, with specific significance for the . tm,cc,jp

Structure and function of otoferlin, a synaptic protein of ... - PMC